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| Titel: |
Graphical Kinetic Approach for Estimation of Various New Constants for Inhibition of Acetylcholinesterase by Cisplatin |
| Auteur: |
Mohammad A. Kamal Faizul H. Nasim Abdulaziz A. Al-Jafari |
| Verschenen in: |
Pakistan journal of biological sciences |
| Paginering: | Jaargang 3 (2000) nr. 6 pagina's 920-923 |
| Jaar: |
2000 |
| Inhoud: |
This study is designed to determine new, rapid and efficient kinetic parameters of the inhibition of human erythrocyte membrane-bound acetylcholinesterase (AChE) by an expensive metallic chemical, "cisplatin". These kinetic parameters in the presence of inhibitor are as follows: Percent maximal activity of the enzyme (Vmc), inhibition rate of the reaction at the first phase of the reaction system (IRr1), inhibition rate of the reaction at the second phase of the reaction system (IRr2), time constant (kt), velocity constant (kv), fifty percent inhibition time (t50), inhibition rate constant (Kir), 50 % inhibition constant (KI50), 99 % inhibition constant (KI99) and overall inhibition constant with respect to time factor (Kis). The current study is a short approach to the investigation of the new kinetic parameters of inhibition of AChE by cisplatin. It is useful approach for the estimation of several inhibition constants of enzymes by variety of chemicals and drugs. |
| Uitgever: |
Asian Network for Scientific Information (provided by DOAJ) |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
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