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| Titel: |
Comaprative Toxicity of the Crabamate Insecticides Bendiocarband Propoxur in Nubian Goats |
| Auteur: |
M. A. Gahelnabi H. M. Mousa B. H. Ali |
| Verschenen in: |
Pakistan journal of biological sciences |
| Paginering: | Jaargang 3 (2000) nr. 12 pagina's 2193-2196 |
| Jaar: |
2000 |
| Inhoud: |
This work examined the sequential development of some clinical, biochemical, hematological and pathological lesions in young Nubian goats given single oral doses of two carbamate insecticides, bendiocarb and propoxur, alone and in combination. The influence of pretreatment with the drug metabolising enzym inducer phenobarbitone was also investigated. Signs of poisoning with both insecticides were dose-related, similar in severity and included restlessness, excessive salivation, arching of the back and recumbancy. All the animal died or were killed 21 to 30 days post treatment. The toxicity caused significant decrease in haemoglobin concentration, haematocrit and erythrocyte numbers. Biochemically, there were significant inhibition of cholinesterase and a rise in aspartate aminotransferase (AST) and lactate dehydrogenase (LDH) indicative of tissue damage. Increase in creatinine and urea were suggestive of renal damage. Histopathologically, there were degeneration and/or necrosis of hepatocytes and of cells of the renal convoluted tubules, congestion in the heart, lungs, kidneys and intestines. Phenobarbitone pretreatment increase the signs of toxicity of both insecticides, indicating that the toxicity may be caused by metabolites of these agents. |
| Uitgever: |
Asian Network for Scientific Information (provided by DOAJ) |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 10 van 84 gevonden artikelen
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