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Details van artikel 5 van 9 gevonden artikelen
| Titel: |
Interferon-Gamma Low Producer Genotype +5644 over presented in Patients with Focal Brucellosis |
| Auteur: |
A. Hedayatizadeh-Omran A. Rafiei M. Hajilooi M. Haghshenas |
| Verschenen in: |
Pakistan journal of biological sciences |
| Paginering: | Jaargang 13 (2010) nr. 21 pagina's 1036-1041 |
| Jaar: |
2010 |
| Inhoud: |
Genetic polymorphisms that affect production levels of certain cytokines may determine the risk, severity or protection in some infectious diseases like brucellosis. IFN-γ plays a key role in the defense mechanism against brucella infection. This study aimed to determine the influence of the polymorphism within the +5644 position of IFN-γ gene on the susceptibility to brucellosis. We investigated the allelic and genotypes distribution of A5644G polymorphism in IFN-γ gene in an Iranian population comprising 259 patients with brucellosis and 238 healthy controls. The single nucleotide polymorphism was determined using the polymerase chain reaction in association with sequence-specific primers (PCR-SSP) incorporating mismatches at the 3'-end. Allelic and genotype frequencies of G5644A polymorphism of IFN-γ gene were not significantly differed between patients with brucellosis and controls (p>0.05). Stratification of patients to focal and non focal diseases revealed a significant increased of 5644A allele in patients with focal brucellosis (79.31% vs. 61.94%, p = 0.0005). Moreover, multivariate logistic regression models showed patients harboring the INF-γ G5644A genotype were significantly more likely to develop focal infectious complications (OR = 3.45, p = 0.0004, 95% CI = 1.26-7.94). The present study suggests that the variant genotypes of G6544A of IFN-γ might be associated with focal form of brucellosis and play as a genetic risk factor in brucellosis. |
| Uitgever: |
Asian Network for Scientific Information (provided by DOAJ) |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 5 van 9 gevonden artikelen
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