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| Titel: |
The Effect of Levamisole on Sheep Trachea Alone and With Trichlorfon Combination |
| Auteur: |
Emine Baydan Ebru Yildirim Sinan Ince |
| Verschenen in: |
Pakistan journal of biological sciences |
| Paginering: | Jaargang 11 (2008) nr. 8 pagina's 1152-1156 |
| Jaar: |
2008 |
| Inhoud: |
The aim of this study is to determine the effect of levamisole and levamisole-trichlorfon combination on isolated sheep trachea. Contraction was achieved with levamisole concentrations (10-8-10-3 M) on tracheal strips of adult sheep (>1 year of age). Pretreatment with trichlorfon (10-7 M)-levamisole (10-7 M) decreased the pD2 and Emax of Ach when compared to levamisole pretreatment (p<=0.01). Pretreatment with levamisole (10-7 M), decreased the Emax (p<=0.01) and pD2 (p<0.05) of bethanechol concentrations (10-8-10-3 M) significantly. Pretreatment with atropine (10-6 M) decreased the Emax of levamisole (10-4 M) significantly (p<0.05). To conclude, levamisole acted mainly on the muscarinic receptors of the sheep trachea and this effect was partly inhibited by atropine. Adverse interaction was present between levamisole and trichlorfon. |
| Uitgever: |
Asian Network for Scientific Information (provided by DOAJ) |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 18 van 20 gevonden artikelen
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