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| Titel: |
Amyloid Deposits in Senile Vertebral Arteries, Immunohistological and Ultrastructural Findings |
| Auteur: |
S. Doostkam J.R.E. Bohl A. Sahraian A.A. Mahjoor |
| Verschenen in: |
Pakistan journal of biological sciences |
| Paginering: | Jaargang 11 (2008) nr. 14 pagina's 1852-1855 |
| Jaar: |
2008 |
| Inhoud: |
In a study on amyloid deposits in vertebral arteries, many elderly patients showed amyloid deposits in the perivascular tissue. These proved to be senile systemic amyloidosis of the transthyretin-type by immunohistochemistry. Amyloid deposits were also found in the arterial wall. These intramural amyloid deposits showed significant affinity to elastic material of the arterial wall. The intramural amyloid deposits did not react with any of the known or available antibodies to amyloid subtypes. Only a polyclonal antibody to human elastin could mark this type of amyloid. It may therefore be assumed that the precursor protein of this amyloid is derived from elastin molecules. By electron microscopy, the light microscopic amyloid deposits were of fibrillary structure, typical for amyloid with a direct contact to elastic material. |
| Uitgever: |
Asian Network for Scientific Information (provided by DOAJ) |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 1 van 24 gevonden artikelen
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