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| Titel: |
Antinociceptive Activity of Methanolic Extract of Epilobium hirsutum |
| Auteur: |
Fereshteh Pourmorad Mohammad Ali Ebrahimzadeh Mitra Mahmoudi Siavash Yasini |
| Verschenen in: |
Pakistan journal of biological sciences |
| Paginering: | Jaargang 10 (2007) nr. 16 pagina's 2764-2767 |
| Jaar: |
2007 |
| Inhoud: |
Antinociceptive activity of methanolic extract of aerial parts of Epilobium hirsutum (EH) was determined in the Hot plate and writhing tests in mice. Nearly all extracts showed a dose dependent and marked analgesic activity in mice in the thermal and chemical models of analgesia when compared to the control. Methanol extract at dose of 500 mg kg-1 showed higher activity (97.7% writhing inhibition) than diclofenac 50 mg kg-1 i.p., (77.8%, p<0.05) and morphine 5 mg kg-1 i.p. (91.2%, p<0.05). Methanol extract, in all tested doses (200-500 mg kg-1) significantly increased the pain threshold in hot plate test (p<0.05). EH extract at 200 mg kg-1 showed a similar effect to morphine at 5 mg kg-1. These finding indicate the potential therapeutic use of methanolic extract of aerial parts of EH as a potent antinociceptive agent. LD50 was obtained 1.5±0.1 g kg-1. EH extract did not induce locomotor impairment in mice at any tested doses. |
| Uitgever: |
Asian Network for Scientific Information (provided by DOAJ) |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 4 van 36 gevonden artikelen
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