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| Titel: |
An in vivo Evaluation of Induction of Abnormal Sperm Morphology by Ivermectin MSD (Mectizan®) |
| Auteur: |
O.A. Otubanjo A.A. Mosuro T. F. Ladipo |
| Verschenen in: |
Pakistan journal of biological sciences |
| Paginering: | Jaargang 10 (2007) nr. 1 pagina's 90-95 |
| Jaar: |
2007 |
| Inhoud: |
The in vivo effects of orally administered ivermectin (Mectizan®) on sperm head morphology of albino mice were evaluated. Four different dose levels of 0.25, 0.5, 1.0 and 1.5 x the human therapeutic dose of 150 g kg-1 body weight, were administered to the animals. The animals were exposed to a single oral treatment. The sperm of the mice from the cauda epididymes were examined 5 and 7 weeks after treatment. Ivermectin (Mectizan®) induced sperm head abnormalities; however, the induction was not significantly elevated above the negative control value. Furthermore, the induction of the sperm head abnormalities was not strictly dose-dependent and there was also no correlation between dose level of administered drug and incidence of abnormal sperms. This indicates that the drug might not be mutagenic. |
| Uitgever: |
Asian Network for Scientific Information (provided by DOAJ) |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 4 van 38 gevonden artikelen
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