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| Titel: |
Analysis of Metabolites of 4-methyl 2-sulfanilamido-oxazole Sulfamethoxazole Excreted in the Urine of Cows |
| Auteur: |
M. I. Baig M. Nawaz M. Z. Iqbal |
| Verschenen in: |
Pakistan journal of biological sciences |
| Paginering: | Jaargang 1 (1998) nr. 3 pagina's 223-225 |
| Jaar: |
1998 |
| Inhoud: |
The urinary excretion and metabolism of 4-Methyl 2- sulfanilamido-oxazole sulfamethoxazole were determined in milking cows following intravenous injection of a single dose 50 mg/kg body weight. The percentage of intravenous dose of 4-Methyl 2- sulfanilamido-oxazole sulfamethoxazole excreted in the urine until 24 hours as total amine was 62.3 ± 4.3 per cent, free amine 52.1 ± 3.8 per cent and acetyl amine was 10.4 ± 1.1 per cent. The mean ± SE values for relative percentage of Metabolite I identified as unchanged amine was 61 per cent. Metabolite II acetyl amine was 19 per cent, Metabolite III hydroxy derivative 8.0 per cent and as conjugated Metabolite were 12.0 per cent. In cows, urinary excretion and Metabolism of 4-Methyl 2-sulfanilamido-oxazole sulfamethoxazole revealed differences apprising as adjustment dosage regimen in the indigenous cows. |
| Uitgever: |
Asian Network for Scientific Information (provided by DOAJ) |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 2 van 28 gevonden artikelen
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