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| Titel: |
Pharmacokinetics of Diminazene Aceturate in Buffalo Calves |
| Auteur: |
Hemant Kumar Pandey Kaushal Kumar Singh Birendra Kumar Roy Suruchi Kumari |
| Verschenen in: |
Journal of bioanalysis & biomedicine |
| Paginering: | Jaargang 02 (2010) nr. 01 pagina's 013-016 |
| Jaar: |
2010 |
| Inhoud: |
The pharmacokinetic study of diminazene aceturate (DMZ) was carried out in two separate groups of 4 each clinically healthy female Murrah buffalo calves after single dose i.v. (8 mg/kg) and i.m. (16 mg/kg) administration. The mean free peak serum concentration of DMZ (CSmax) after i.v. (26.28±0.67μg/ml) and i.m. (8.41±2.43 μg/ml) administrations were obtained at tmax of 5 and 30 min respectively. The DMZ serum concentrations time data were best fitted to the two compartment open model. The calculated serum half life (t½ β) values of DMZ were 15.099±2.504 and 14.225±2.682 h after i.v. and i.m. administration respectively. The mean values of total body clearance rate of DMZ (ClB) after i.m. (3.785±1.119 ml/kg/min) was significantly higher (P<0.05) as compared with the i.v. (0.537±0.063 ml/kg/min). DMZ was highly bound (77.14 to 94.40%) to buffalo calf plasma protein and its penetration into erythrocytes increased with increasing concentrations in blood (7.60to 33.00μg/ml). Based on pharmacokinetic profiles, the satisfactory dosage regimens of diminazene aceturate in buffalo calves were derived (2 mg/kg, i.v. and 12mg/kg, i.m). In case of emergent disease conditions to ensure high DMZ serum concentrations, i.v. route may be preferred over i.m. route. |
| Uitgever: |
OMICS Publishing Group (provided by DOAJ) |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
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