|
| << vorige | volgende >> |
Tijdschrift beschrijving
Alle jaargangen van het bijbehorende tijdschrift
Alle afleveringen van het bijbehorende jaargang
Alle artikelen van de bijbehorende aflevering
Details van artikel 79 van 149 gevonden artikelen
| Titel: |
Murine brain endothelial cells differently modulate interferon-γ and interleukin-17 production in vitro |
| Auteur: |
Momčilović Miljana Miljković D. Mostarica-Stojković Marija |
| Verschenen in: |
Archives of biological sciences |
| Paginering: | Jaargang 61 (2009) nr. 1 pagina's 29-36 |
| Jaar: |
2009 |
| Inhoud: |
Brain endothelial cells (BEC) are the major constituents of the blood-brain barrier (BBB), the structure that controls entrance of immune cells into CNS parenchyma. Our aim was to investigate the influence of BEC on production of IL-17 and IFN-γ-cytokines that are important for CNS inflammation. To that end, co-cultivations of the bEnd.3 brain endothelial cell line and lymph node cells (LNC) were performed, and gene expression and production of IL-17 and IFN-γ were determined. It was found that bEnd.3 cells inhibited expression and production of IFN-γ, but not of IL-17. Additionally, bEnd.3 cells also reduced production of the major IFN-γ-promoting cytokine - IL-12 - in LNC. The observed variation in modulation of pro-inflammatory cytokines by BEC could be of importance for the understanding of CNS inflammation. |
| Uitgever: |
Srpsko biološko društvo, Institut za biološka istraživanja "Siniša Stanković", Biološki fakultet Univerziteta u Beogradu, Institut za primenu nuklearne energije u poljoprivredi, šumarstvu i veterinarstvu (provided by DOAJ) |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 79 van 149 gevonden artikelen
| << vorige | volgende >> |