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| Titel: |
Fumagillin-induced chromosome aberrations in mouse bone-marrow cells |
| Auteur: |
Stanimirović Z. Aleksić Nevenka Kulić M. Maletić M. |
| Verschenen in: |
Archives of biological sciences |
| Paginering: | Jaargang 62 (2010) nr. 1 pagina's 47-55 |
| Jaar: |
2010 |
| Inhoud: |
The genotoxicity of fumagillin was evaluated assessing the mitotic index and chromosome aberrations in mouse bone-marrow cells. Mice were given fumagillin orally in doses 5, 10 and 20 mg/kg bw. All doses significantly (p<0.001) reduced the mitotic index. The medium and maximum doses led to significant (p<0.01 and p<0.001, respectively) increases in numeric aberrations. The highest dose induced both structural and numeric aberrations (p<0.001), and insertions on the first pair of autosomes that were amplified in the 1C and 1E regions. These results pointed to the genotoxic potential of fumagillin in the range of medium and maximum doses applied. |
| Uitgever: |
Srpsko biološko društvo, Institut za biološka istraživanja "Siniša Stanković", Biološki fakultet Univerziteta u Beogradu, Institut za primenu nuklearne energije u poljoprivredi, šumarstvu i veterinarstvu (provided by DOAJ) |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 55 van 149 gevonden artikelen
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