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| Titel: |
Uterus-Relaxing Study of a Sudanese Herb (El-Hazha) |
| Auteur: |
Judit Hohmann Mahmoud Mudawi Eltahir Mudawi Andrea Vasas Arpad Marki Robert Gaspar Aimun Abdelgaffar Elhassan Ahmed George Falkay |
| Verschenen in: |
American journal of biochemistry and biotechnology |
| Paginering: | Jaargang 6 (2010) nr. 3 pagina's 231-238 |
| Jaar: |
2010 |
| Inhoud: |
Problem statement: The aim of this study is to investigate the pharmacological effects of the Methanolic-extract (AH2) of El-Hazha and its sub-fractions. Approach: These investigations were carried out on in vitro isolated uterus preparations from Non-Pregnant (NP) and Late-Pregnant rats (LP). In parallel displacement radio-ligand binding assay was performed for β-Adrenergic Receptors (β-ADR). Results: Showed that the herb and its different fractions produced dose-dependent relaxant effect (p<0.05, t-test, n = 6) on uterine contraction elicit by 25 mM KCl in both NP and LP uteri that affected significantly by fractionation, however, the effect of the most active fraction (AH2-11) was reversed by prior addition of propranolol (non-specific β-antagonist), but not affected by progesterone pre treatment of the LP rats. In addition, AH2 only in high concentration displaced isotopes from β-ADR, this affinity changed markedly by fractionation. Conclusion: We validate the fractionation effect on its relaxant activity and found partial role for β-ADR on mediating this activity. Future study was recommended to isolate and investigate its active components to enhance this activity or to discover a new novel natural therapeutic agent(s). |
| Uitgever: |
Science Publications (provided by DOAJ) |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
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