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                                       Details for article 17 of 18 found articles
 
 
  Serotonergic Properties of the Roots of Clerodendron capitatum
 
 
Title: Serotonergic Properties of the Roots of Clerodendron capitatum
Author: Siddig Ibrahim Abdel Wahab
Abdel Wahab Hassan Mohamed
Osama Yousif Mohamed
Manal Mohamed Elhassan Taha
Ahmad Bustamam Abdul
Adel Sharaf Al-Zubairi
Appeared in: American journal of biochemistry and biotechnology
Paging: Volume 4 (2008) nr. 4 pages 425-430
Year: 2008
Contents: The aim of this study is to investigate the pharmacological effects of the methanolic extract of Clerodendron capitatum, CC, (family verbenaceae). These investigations were carried out on isolated frog rectus abdominus muscle and rabbit aortic strips and jejunum and non-pregnant rat uterus pretreated with oestradiol. Results showed that CC did not demonstrate any contracting, relaxant or blocking effects on frog rectus abdominus muscle and rat aortic strip preparations. The extract produced a concentration-dependent (p<0.05, t-test, n = 6) decrease of the normal rhythmic contraction of rabbit jejunum, however, this effect was reversed by prior addition of cyproheptadine (non-specific 5-HT antagonist). In addition, CC also produced a stimulant activity on rat uterus which was blocked by cyproheptadine. Future study is recommended to study the specificity of CC to different 5-HT receptors by using different isolated animal tissues and specific 5-HT antagonists.
Publisher: Science Publications (provided by DOAJ)
Source file: Elektronische Wetenschappelijke Tijdschriften
 
 

                             Details for article 17 of 18 found articles
 
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