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                                       Details van artikel 5 van 12 gevonden artikelen
 
 
  5-Hydroxytryptamine Induces Electrogenic Secretion in the Duodenum of Gerbil (Gerbillus cheesmani )
 
 
Titel: 5-Hydroxytryptamine Induces Electrogenic Secretion in the Duodenum of Gerbil (Gerbillus cheesmani )
Auteur: Fawzia Y. Al-Balool
Verschenen in: American journal of biochemistry and biotechnology
Paginering: Jaargang 3 (2007) nr. 3 pagina's 114-117
Jaar: 2007
Inhoud: The effect of serosally added 5-hydroxytryptamine (5-HT 100 M) on the short circuit-current (Isc) across duodenum taken from fed, starved (4 days, water ad lib) and undernourished (50% control food intake for 21 days) gerbils (Gerbillus cheesmani) were investigated. The effect of the neurotoxin, tetrodotoxin (TTX 10 M) and atropine (100M) on the maximum increase in Isc induced by 5-HT were also studied. The 5-HT-induced Isc were higher in unstripped than in the stripped sheets in the three feeding conditions. TTX reduced the maximum increase in Isc induced by 5-HT across stripped and unstripped sheets taken from fed, starved and undernourished gerbils. Atropine decreased the 5-HT-induced Isc of stripped sheets in the three feeding conditions and it also decreased the 5-HT-induced Isc in unstripped sheets in fed duodenum. Therefore, the duodenal response to 5-HT occur partly by activation of a nonneural pathway and partly by activating electrogenic ion transport via muscarinic neural mechanism. It also showed that the 5-HT-induced Isc was chloride-dependent in fed duodenum and were chloride and bicarbonate dependent in the duodenum taken from starved and undernourished gerbil The results also showed that the increase in 5-HT-induced Isc as a results of starvation and undernourishment were TTX-sensitive and both chloride and bicarbonate dependent.
Uitgever: Science Publications (provided by DOAJ)
Bronbestand: Elektronische Wetenschappelijke Tijdschriften
 
 

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