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| Titel: |
Comparative Modeling Study of the 3-D Structure of Small Delta Antigen Protein of Hepatitis Delta Virus |
| Auteur: |
Singh Sarita Gupta Sunil Kumar Nischal Anuradaha Khattri Sanjay Nath Rajendra |
| Verschenen in: |
Journal of computer science and systems biology |
| Paginering: | Jaargang 03 (2010) nr. 01 pagina's 001-004 |
| Jaar: |
2010 |
| Inhoud: |
Delta hepatitis is pandemic worldwide, which is causedby Hepatitis delta Virus (HDV) an RNA virus. HDV causeseither co-infection or super infection with Hepatitis B virus.Small delta antigen protein of HDV is obligatory forreplication of virus. Since it plays a crucial role in viruslife cycle, it may be a suitable target for drug development.Three dimensional structure of protein is of greatsignificance for the rational design of many different typesof biological experiments. In current study 3-D modelingof small delta antigen protein was performed by usingGenThreader followed by modeller9v7. The validation ofpredicted 3-D structure was done using PROCHECK,Anolea, Gromos96 and Swisspdb-viewer tools. CASTpwas used further to study surface features and functionalbinding pockets in protein. The resulting 3-D model canbe used to develop novel inhibitor against small delta antigenprotein to cure the disease. |
| Uitgever: |
OMICS Publishing Group (provided by DOAJ) |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 6 van 29 gevonden artikelen
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