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Details for article 27 of 29 found articles
| Title: |
The Genetic Equidistance Result of Molecular Evolution is Independent of Mutation Rates |
| Author: |
Shi Huang |
| Appeared in: |
Journal of computer science and systems biology |
| Paging: | Volume 01 (2008) nr. 01 pages 092-102 |
| Year: |
2008 |
| Contents: |
The well-established genetic equidistance result shows that sister species are approximately equidistant to a simpler outgroup as measured by DNA or protein dissimilarity. The equidistance result is the most direct evidence, and remains the only evidence, for the constant mutation rate interpretation of this result, known asthe molecular clock. However, data independent of the equidistance result have steadily accumulated in recent years that often violate a constant mutation rate. Many have automatically inferred non-equidistance whenever a non-constant mutation rate was observed, based on the unproven assumption that the equidistance result is anoutcome of constant mutation rate. Here it is shown that the equidistance result remains valid even when different species can be independently shown to have different mutation rates. A random sampling of 50 proteins shows that nearly all proteins display the equidistance result despite the fact that many proteins have nonconstant mutation rates. Therefore, the genetic equidistance result does not necessarily mean a constant mutation rate. Observations of different mutation rates do not invalidate the genetic equidistance result. New ideas are needed to explain the genetic equidistance result that must grant different mutation rates to different species and must be independently testable. |
| Publisher: |
OMICS Publishing Group (provided by DOAJ) |
| Source file: |
Elektronische Wetenschappelijke Tijdschriften |
Details for article 27 of 29 found articles
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