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Details for article 10 of 21 found articles
| Title: |
Efficacy of Vancoplus Against Intra Abdominal Infected Mice: A Novel Fixed Dose Combination of Ceftriaxone Plus Vancomycin |
| Author: |
A. Soni V.K. Dwivedi M. Chaudhary |
| Appeared in: |
Journal of biological sciences |
| Paging: | Volume 9 (2009) nr. 7 pages 655-661 |
| Year: |
2009 |
| Contents: |
The study was planned to monitor antioxidant and extracellular parameters on different days of interval in blood of infected and treated groups of mice during abdominal infection by treatment of ceftriaxone plus vancomycin (vancoplus). Fifty-four young Mus musculus mice were divided into three groups as follows: control group (n = 6), infected group (n = 24) and treated with CV group (n = 24). Intraperitonial injection of Escherichia coli (1x106cfu) was given for intra abdominal infection. FDC of CV was administered intravenously in the dosage of 42.8 mg kg-1 body twice daily for 7 days. The activities of antioxidant enzymes such as superoxide dismutase and catalase as well as the concentration of malonaldialdehyde, as an indicator of lipid peroxidation were measured to evaluate oxidative stress in blood. A significant increased in malonaldialdehyde, creatinine and uric acid levels (p<0.001) were found in infected group when compared to control and treated groups. Superoxide dismutase (p<0.01) and catalase (p<0.001) activities were found to be decreased in infected group as compared to control and treated groups. It can be concluded that ceftriaxone-vancomycin shows broad spectrum against E. coli and prevent oxidative damage of tissue injury by reducing reactive oxygen species. These finding suggests that, based on their anti-oxidative capability, these agents could provide benefit in anti-infective therapy and reduces safely relief against intra-abdominal infection. |
| Publisher: |
Asian Network for Scientific Information (provided by DOAJ) |
| Source file: |
Elektronische Wetenschappelijke Tijdschriften |
Details for article 10 of 21 found articles
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