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| Titel: |
Comparative Bioavailability of Two Brands of Ofl oxacin in Healthy Human Volunteers |
| Auteur: |
Rajani Shakya Manila Hada Panna Thapa R. N. Saha |
| Verschenen in: |
Journal of bioequivalence & bioavailability |
| Paginering: | Jaargang 02 (2010) nr. 03 pagina's 055-058 |
| Jaar: |
2010 |
| Inhoud: |
<p> The relative bioavailability and pharmacokinetics of a locally manufactured (Oquin) and reference (Zanocin) formulations of ofl oxacin were compared. Each volunteer received a single dose of 200 mg ofl oxacin tablet, test or reference with a 7 days washout period. Multiple blood samples were collected and plasma concentrations of ofl oxacin were analyzed by high performance liquid chromatography technique.</p><p> Following oral administration of both formulations, there was rapid and extensive oral absorption from gastrointestinaltract achieving maximum serum concentration within 2 hrs. The concentration-time profi le generated by the two productswas found to be superimposable. Peak plasma concentration (Cmax), area under the serum concentration-time curve(AUC0-24), area under the serum concentration-time curve extrapolated to infi nity (AUC0-∞) and serum elimination halflife (t½) were 1.98 ± 0.213 and 1.82 ± 0.194 μg/ml, 13.19 ± 1.45 and 12.56 ± 0.965 μg.hr/ml, 13.86 ± 1.49 and 13.14 ±0.959μg.hr/ml, 5.55 ± 1.37 and 5.55 ± 0.715 hr for Oquin and Zanocin, respectively.</p><p> The result indicates that these two formulations have similar rate as well as extent of absorption. Hence these two products can be said to have comparable bioavailability. </p> |
| Uitgever: |
OMICS Publishing Group (provided by DOAJ) |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
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