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| Titel: |
Protective effect of apigenin hydrogen peroxide induced genotoxic damage on cultured human peripheral blood lymphocytes |
| Auteur: |
Yasir Hasan Siddique Mohammad Afzal |
| Verschenen in: |
Journal of applied biomedicine |
| Paginering: | Jaargang 7 (2009) nr. 1 pagina's 35-43 |
| Jaar: |
2009 |
| Inhoud: |
Apigenin is a member of the flavone family of flavonoids and possesses anti-inflammatory, free radicalscavenging and anti-carcinogenic properties. Hydrogen peroxide, which is generated during oxidative stress,is known to damage proteins, nucleic acids and cell membranes and also has been implicated in cancer, ageingand several chronic neurogenerative diseases. The present study focuses on the protective effect of apigeninagainst genotoxic doses of hydrogen peroxide (H2O2) using sister chromatid exchanges (SCEs) andcytokinesis blocked micronucleus (CBMN) assay. The treatment with 50, 100 and 150 μM of H2O2 resultsin a significant dose dependent increase in the frequency of SCEs and MN. The treatment with 100 μM ofH2O2 along with 5, 10 and 20 μM of apigenin results in a dose dependent significant decrease in the frequencyof SCEs and MN on cultured human lymphocytes. A similar result was obtained with treatment with 150 μMof H2O2 along with 5, 10 and 20 μM of apigenin. The results of the present study suggest a protective effectof apigenin against hydrogen peroxide induced genotoxic damage on cultured human lymphocytes. |
| Uitgever: |
University of South Bohemia (provided by DOAJ) |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 5 van 5 gevonden artikelen
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