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| Titel: |
Clock genes in health and diseases |
| Auteur: |
Valerie Mongrain Nicolas Cermakian |
| Verschenen in: |
Journal of applied biomedicine |
| Paginering: | Jaargang 7 (2009) nr. 1 pagina's 15-33 |
| Jaar: |
2009 |
| Inhoud: |
Circadian rhythms, rhythms of about 24 h in various physiological functions, are getting extensivelycharacterized at the molecular level. The generation of circadian rhythms is acknowledged to originate fromoscillations in the expression of several clock genes as well as in the regulation of their protein products.While the general entrainment of organisms to the light-dark cycle of the environment is mainly achievedthrough the master clock of the suprachiasmatic nucleus in mammals, the molecular clockwork is functionalin various organs and tissues. The molecular components of the circadian system have been found to beessential for a diversity of basic and homeostatic systems ranging from the control of cell cycle, the regulationof cardiac and metabolic function, to the fine-tuning of sleep and mental health. The present review will focuson the involvement of clock genes in human health and diseases. |
| Uitgever: |
University of South Bohemia (provided by DOAJ) |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 3 van 5 gevonden artikelen
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