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| Titel: |
Distribution of cyclooxygenase-1 and cyclooxygenase-2 in the mouse seminal vesicle |
| Auteur: |
Thotakura Balaji Manickam Ramanathan Marimuthu Srinivasan Venugopal Padmanabhan Menon |
| Verschenen in: |
Journal of applied biomedicine |
| Paginering: | Jaargang 6 (2008) nr. 2 pagina's 97-104 |
| Jaar: |
2008 |
| Inhoud: |
Cyclooxygenase is the enzyme responsible for the production of prostaglandins (PGs). This cyclooxygenaseexists in two isoforms: cyclooxygenase-1 (COX-1) and cyclooxygense-2 (COX-2). In humans and primateshigh levels of COX-2 are detected in the seminal vesicle. Further, the main source of PGs in the semen ofthese species is from the seminal vesicle. In rodents, the source of PGs in semen is from the vas deferens andabundant levels of COX-2 are detected. A direct relation is thought to exist between COX-2 levels and thesource of PGs in semen. Moreover, the role of COX-1 and COX-2 in the seminal vesicle of rodents isobscure. The present study aims at localizing COX-1 and COX-2 in the seminal vesicle of mice.Immunohistochemical staining and COX activity assay revealed COX-1 as a dominant isoform in the mouseseminal vesicle. On treatment with nimesulide – a preferential COX-2 inhibitor - no change in stainingintensity and COX activity was observed. The total PG levels also appeared to be unaltered followingnimesulide treatment. This confirms that nimesulide had no effect on COX-1. The results presented heresuggest COX-1 is the dominant isoform in the mouse seminal vesicle and is responsible for PG synthesis. |
| Uitgever: |
University of South Bohemia (provided by DOAJ) |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 4 van 8 gevonden artikelen
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