Development of cardiac conduction system in mammals with a focus on the anatomical, functional and medical/genetical aspects
Titel:
Development of cardiac conduction system in mammals with a focus on the anatomical, functional and medical/genetical aspects
Auteur:
David Sedmera
Verschenen in:
Journal of applied biomedicine
Paginering:
Jaargang 5 (2007) nr. 3 pagina's 115-123
Jaar:
2007
Inhoud:
Recent progress in search of mechanisms regulating the spatio-temporal formation of specializedconduction tissues pushes us further in our understanding of the developmental molecular mechanismsof myocardial patterning. It is not clear which mechanisms direct the fates of chamber myocytes todifferentiate into ventricular cardiac conduction system (CCS). Similarly, the formation and nature ofconnections between its most distal component, the Purkinje fibers, and the working myocytes, isunresolved. The process of remodelling of originally ring-like AV junction into AV node andaccompanying fibrous insulation between the atria and ventricles is poorly understood, especially onthe molecular level. Perturbation of this process can result in abnormal atrio-ventricular connections,manifesting as Wolf-Parkinson-White syndrome of ventricular pre-excitation. Understanding thesignalling mechanisms involved in CCS development may be of significance to clinicians and basicresearchers studying adult cardiac disease. Congenital abnormalities in CCS, as well as ectopic orinappropriate induction of CCS tissue in the mature heart, may be processes that contribute to, orcause, cardiac conduction disturbance and arrhythmia in adults. Understanding the signallingmechanisms that give rise to normal development of the CCS may thus provide insight into cardiacdisease.
Tijdschrift beschrijving