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| Titel: |
Urtica dioica extract reduces platelet hyperaggregability in type 2 diabetes mellitus by inhibition of oxidant production, Ca2+ mobilization and protein tyrosine phosphorylation |
| Auteur: |
Mohammed El Haouari Isaac Jardin Hasane Mekhfi Juan A. Rosado Gines M. Salido |
| Verschenen in: |
Journal of applied biomedicine |
| Paginering: | Jaargang 5 (2007) nr. 2 pagina's 105-113 |
| Jaar: |
2007 |
| Inhoud: |
Platelet hyperaggregability is involved in the pathogenesis of type 2 diabetes mellitus. Thrombin-evokedplatelet aggregation includes the activation of several intracellular pathways, including endogenousgeneration of reactive oxygen species (ROS), Ca2+ mobilization and protein tyrosine phosphorylation.Here we show that crude aqueous extract from Urtica dioica reduces thrombin-evoked aggregation inplatelets from healthy donors and diabetics, in a concentration-dependent manner. U. dioica extractshowed a potent antioxidant activity and prevented thrombin-evoked ROS generation in platelets fromhealthy and diabetic donors. Treatment with U. dioica extract reduced Ca2+ entry induced by thrombin orselective depletion of the two Ca2+ stores in platelets (without altering Ca2+ release), reduced proteintyrosine phosphorylation and reversed the abnormal Ca2+ mobilization and tyrosine phosphorylation inplatelets from diabetics. We conclude that extract from U. dioica shows antiaggregant actions and mightbe used for the treatment and/or prevention of cardiovascular complications associated with type 2diabetes mellitus. |
| Uitgever: |
University of South Bohemia (provided by DOAJ) |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 8 van 8 gevonden artikelen
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