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| Titel: |
Genetic determination of an endothelial function and the size of the heart sections in juvenile hypertensives |
| Auteur: |
Vera Adamkova Jaroslav A. Hubacek Helena Pistulkova Hana Malinska Jelena Skibova |
| Verschenen in: |
Journal of applied biomedicine |
| Paginering: | Jaargang 4 (2006) nr. 2 pagina's 59-65 |
| Jaar: |
2006 |
| Inhoud: |
Arterial hypertension is a polygenic disease and about 50 candidate genes have been analysed. Wefollowed the size of the heart sections and the endothelial function in juvenile hypertensives according tothe polymorphisms in the genes for angiotensin converting enzyme (I/D), endothelin 1 (Lys198/Asn) andendothelin 1 converting enzyme (Thr341/Ile).We observed 44 juvenile hypertensives and 94 controls of the same age. An echocardiographicexamination was carried out during standard examinations. The endothelial function was analysed withthe use of ultrasound with high acuity after revoking a reactive hyperaemia. The genotypisations wereperformed using the polymerase chain reaction and restriction analysis. Statistical analyses were carriedout using the BMDP statistical software.There were no differences between controls and hypertensives in alleles frequency. Thehypertensives differed from the control group in the endothelial function (statistically significant). Thehypertensives homozygotes D/D and the heterozygotes Lys198/Asn had a larger left ventricle(statistically significant); the hypertensives with the Thr341/Ile had a larger left ventricle septum(statistically significant) and back wall of the left ventricle (statistically significant) than the controls withthe same genotype.We concluded that the genes for ACE, endothelin 1 and endothelin 1 converting enzyme have aninfluence on the size of the heart sections and on the endothelial function of the juvenile hypertensives. |
| Uitgever: |
University of South Bohemia (provided by DOAJ) |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 3 van 6 gevonden artikelen
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