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| Titel: |
Tea tree oil inhalations modify immunity in mice |
| Auteur: |
Mateusz Golab Oleg Burdzenia Pawel Majewski Krystyna Skwarlo-Sonta |
| Verschenen in: |
Journal of applied biomedicine |
| Paginering: | Jaargang 3 (2005) nr. 2 pagina's 101-108 |
| Jaar: |
2005 |
| Inhoud: |
Tea tree oil (TTO) is well known as an anti-microbial and immunomodulatory agent and the latterproperty was examined in this study. Male, C57BI10 x CBA/H (F1), mice were exposed to TTO vapourthree times a day, for one week. During this period, half of the mice also received naltrexone (endogenousopioid receptor antagonist) in their drinking water. A day before the end of the TTO inhalation treatment anumber of the mice were intra-peritoneally injected with Zymosan or PBS. Spleens and peritonealexudates were collected 24 h after the injections. Cultured splenocytes were used in in vitro proliferationassays with PHA, and LPS mitogens and peritoneal leukocytes (PTLs) were used for cytofluorimetricROS level measurement.The results obtained confirmed the anti-inflammatory properties of TTO, expressed as an inhibitionof the increase in the PTL number stimulated by Zymosan. This effect was reversed by naltrexone,suggesting that TTO acts via the endogenous opioid system. TTO also stopped the proliferation ofsplenocytes in response to mitogens and the activity of PTLs was equivalent to that seen in the control(without inflammation) groups. |
| Uitgever: |
University of South Bohemia (provided by DOAJ) |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 6 van 6 gevonden artikelen
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