Biochemical and haematological differentiation of opiate addicts from healthy subjects. A case control study
Titel:
Biochemical and haematological differentiation of opiate addicts from healthy subjects. A case control study
Auteur:
Jose Fernando Diaz-Flores Estevez Felicitas Diaz-Flores Estevez Carlos Hernandez Calzadilla Elena Maria Rodriguez Rodriguez Carlos Diaz Romero Lluis Serra-Majem
Verschenen in:
Journal of applied biomedicine
Paginering:
Jaargang 3 (2005) nr. 1 pagina's 37-46
Jaar:
2005
Inhoud:
The biochemical and haematological parameters of nutritional interest were determined in theserum of opiate addicts in order to compare them with those obtained in healthy subjects. Theblood of 106 opiate addicts in detoxification treatment (n=19) or in Methadone MaintenanceTreatment Program (MMTP) (n=87) was studied. Opiate addicts presented lower levels in thenumber of red cells, cholesterol, albumin, retinol, α-tocopherol, folic acid, K and Se and higherlevels in the number of leukocytes, GOT, GPT and Na, than the control group. The opiate addictsin MMTP had higher levels of glucose, triglycerides, Mg and P than the opiate addicts in thedetoxification treatment and control groups. Significant correlations between the three vitamins(folic acid, retinal and α-tocopherol) were observed and the graphic representations suggest abiochemical differentiation between opiate addicts and healthy subjects. Factor analysis made itpossible to select seven factors explaining 66.2% of the total variance, and representing the firstand fourth factor, opiate addicts tended to separate from the control group.