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| Titel: |
The therapeutic efficacy of oxime treatment in cyclosarin-poisoned mice pretreated with a combination of pyridostigmine benactyzine and trihexyphenidyl |
| Auteur: |
Lucie Sevelova Kamil Kuca Gabriela Krejcova Josef Vachek |
| Verschenen in: |
Journal of applied biomedicine |
| Paginering: | Jaargang 2 (2004) nr. 3 pagina's 163-167 |
| Jaar: |
2004 |
| Inhoud: |
The present study was performed to assess and compare the therapeutic efficacy of variousoximes (methoxime, BI-6, HI-6) combined with benactyzine (BNZ) in cyclosarin (GF-agent)-poisoned mice and to evaluate the influence of pretreatment with PANPAL (pyridostigmine,benactyzine and trihexyphenidyl) on the effect of antidotal treatment in mice poisoned withthe GF-agent. In the first part of our experiment, methoxime, BI-6 or HI-6 in combinationwith benactyzine were used for the treatment of GF-poisoned mice. In the second part of theexperiment the animals were pretreated with PANPAL 60 min before the GF-agent challengeand then the oxime therapy was applied in the same time scheme as before. All thetherapeutic regimens showed a protective ratio higher than 2 and significantly increased theLD50 of GF-agent. The most efficacious oxime in decreasing of GF-agent toxicity was HI-6.PANPAL increased the protective ratios of all therapeutic regimens in comparison withadministration of the oxime and BNZ alone. From the results obtained, the combination ofpretreatment with PANPAL and following therapy with BNZ and HI-6 seems to be the mostefficacious therapeutic regimen for treatment of GF-agent-poisoned mice. |
| Uitgever: |
University of South Bohemia (provided by DOAJ) |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 6 van 6 gevonden artikelen
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