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| Titel: |
The significance of stem cells in free-living flatworms: one common source for all cells in the adult |
| Auteur: |
Roland Peter Robert Gschwentner Wolfgang Schurmann Reinhard M. Rieger Peter Ladurner |
| Verschenen in: |
Journal of applied biomedicine |
| Paginering: | Jaargang 2 (2003) nr. 1 pagina's 21-35 |
| Jaar: |
2003 |
| Inhoud: |
A survey of the current knowledge on stem cells and cell proliferation in turbellarians is presented,with special focus on recent results obtained by the authors when studying cell kinetics andcultivating neoblasts from various species. Differentiated somatic cells do not divide in flatworms.In these animals neoblasts constitute a proliferative compartment. These cells are rather uniformwhen viewed through a light microscope, but constitute a heterogeneous population comprisingactual stem cells, progenitors and early differentiation stages. Cell kinetics were monitored by theincorporation of 5-bromo-2ยด-deoxyuridine and by immunocytochemical staining for mitoses in themarine microturbellarians Macrostomum, Microstomum and Convolutriloba. Distribution patterns ofproliferating cells within the body were documented, and a tentative interpretation of thedifferences observed is given. Correlations to the nervous system and the mode of reproductionseem to exist. To analyse neoblasts quantitatively and establish primary cultures, neoblasts fromthe freshwater planarians (triclads) Dugesia and Schmidtea were isolated, purified and subjected tovarious culture conditions, with the ultimate but not yet achieved goal of establishing a permanentstem cell line. The role of stem cells in flatworms is compared with the situation in mammals, withspecial focus on embryogenesis, germline and strategies of cell renewal. |
| Uitgever: |
University of South Bohemia (provided by DOAJ) |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
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