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Details van artikel 5 van 8 gevonden artikelen
| Titel: |
Microscopic image analysis of elastin network in samples of normal, atherosclerotic and aneurysmatic abdominal aorta and its biomechanical implications |
| Auteur: |
Zbynek Tonar Stanislav Nemecek Radek Holota Jitka Kocova Vladislav Treska Jiri Molacek Tomas Kohoutek Sarka Hadravska |
| Verschenen in: |
Journal of applied biomedicine |
| Paginering: | Jaargang 1 (2003) nr. 3 pagina's 149-159 |
| Jaar: |
2003 |
| Inhoud: |
The aim of our work was to prepare part of the input data for a computational biomechanicalmodel of both the active and passive elements of the tunica media of an aortic aneurysm. Weanalyzed tissue samples of the anterior wall of the normal, atherosclerotic and aneurysmatic subrenalabdominal aorta. We assessed the proportions of smooth muscle cells, elastin and collagen inhistological sections of these samples and studied the morphological characteristics of the elastinnetwork in the tunica media. Selected photomicrographs were studied, representing relatively wellpreserved areas without artifacts, ruptures, corrupted integrity of the tunica media or totalelastinolysis. A new method was introduced for the assessment of structures formed by elastinmembranes and fibres, using the fast Fourier transform (FFT) technique. The image was transformedinto reciprocal (Fourier) space and the method made use of the fact that the FFT was verysensitive to the orientation distribution of thresholded elastin morphology. The results of thiscomparative study, obtained from selected samples from 24 patients, revealed that the percentagevalues of the constituents of the arterial wall can not distinguish between the preserved segments ofnormal, atherosclerotic or aneurysmatic aorta. The results of the Fourier analysis proved that theFFT provided an efficient method for evaluating cross sections of the elastin membranes andfibres, reflecting their anisotropy. The shape of the power spectrum of elastin was a simple pattern,whose description was quantified by the shape of its polar coordinates histogram. We discuss themethodological difficulties and biomechanical implications of our work as well compare it to othermethods of elastin analysis. |
| Uitgever: |
University of South Bohemia (provided by DOAJ) |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 5 van 8 gevonden artikelen
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