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| Titel: |
The chemistry, pharmacology, and toxicology of the biologically active constituents of the herb Hypericum perforatum L. |
| Auteur: |
Jiri Patocka |
| Verschenen in: |
Journal of applied biomedicine |
| Paginering: | Jaargang 1 (2003) nr. 2 pagina's 61-70 |
| Jaar: |
2003 |
| Inhoud: |
St. John's wort (Hypericum perforatum) has been used as a medical herb for over 2000 years. Overthe past two decades, its application as a standardized plant extract for treating depression hasundergone rigorous scientific investigation, and its effectiveness has been shown in studiescomparing it with other commonly used antidepressants and placebos. Safety and tolerability studieshave revealed that Hypericum preparations have better safety and tolerability profiles than syntheticantidepressants. The indications for St. John's wort preparations are mild or moderate depression.The mechanism of the antidepressant action of Hypericum extract is not fully known. The view ofthe chemical composition and pharmaceutical a toxicological properties of biologically activesubstances of Hypericum perforatum is the main purpose of this paper. |
| Uitgever: |
University of South Bohemia (provided by DOAJ) |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
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