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| Titel: |
Antidepressant, Myorelaxant and Anti-Anxiety-Like Effects of Nauclea latifolia Smith (Rubiaceae) Roots Extract in Murine Models |
| Auteur: |
G.S. Taiwe E. Ngo Bum T. Dimo E. Talla N. Weiss A. Dawe F.C.O. Moto N. Sidiki P.D. Dzeufiet M. De Waard |
| Verschenen in: |
International journal of pharmacology |
| Paginering: | Jaargang 6 (2010) nr. 4 pagina's 364-371 |
| Jaar: |
2010 |
| Inhoud: |
The neuropharmacological effects of the decoction of Nauclea latifolia Smith (Rubiaceae) roots were studied in mice. Different experimental models (forced swimming test, horizontal wire test and hole-board test) were used for detecting antidepressant, myorelaxant and anxiolytic properties. The results revealed that Nauclea latifolia induced a reduction of immobility, in a similar way to that of fluoxetine, along with a significant increase in the percentage of spent time in swimming behavior. Nauclea latifolia displayed a myorelaxant activity in the horizontal wire test. In the hole-board test, Nauclea latifolia significantly increased the number and duration of head-dips. In addition, anxiolytic-like properties of Nauclea latifolia were blocked by anxiogenic agents as examined in the hole-board test. This was the case for N-methyl-?-carboline-3-carboxamide (FG7142), a partial inverse agonist at the benzodiazepine site of the GABAA receptor complex, flumazenil (RO151788), a central benzodiazepine receptor antagonist and bicuculline, a light-sensitive competitive antagonist of GABAA receptors. These results suggest that Nauclea latifolia roots decoction possess antidepressant, myorelaxant and anti-anxiety-like properties in the models employed. The extracts might potentially act by GABAergic activation and/or by modulating the serotoninergic levels in the central nervous system. However, further studies were still required. |
| Uitgever: |
Asian Network for Scientific Information (provided by DOAJ) |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 3 van 28 gevonden artikelen
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