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Details van artikel 25 van 28 gevonden artikelen
| Titel: |
Studies of Behavioural and Neural Mechanism of Aridanin Isolated from Tetrapleura tetraptera in Mice |
| Auteur: |
A.O. Aderibigbe E.O. Iwalewa S.K. Adesina O.I. Agboola |
| Verschenen in: |
International journal of pharmacology |
| Paginering: | Jaargang 6 (2010) nr. 4 pagina's 480-486 |
| Jaar: |
2010 |
| Inhoud: |
The aim of the present study was to investigate the central nervous system depressant effect and neural mechanisms of Aridanin in mice. Novelty-induced rearing, head dips, locomotor activity and effect on learning and memory were studied. Aridanin at 5, 10, 20 and 30 mg kg-1 b.wt. reduced novelty-induced rearing and locomotor activity in mice. Head dip reduction was noticed only with the highest dose (30 mg kg-1, i.p.) while in Y-maze, a reduction in number of entrance (locomotion) with no change in percentage alternation on short term working memory was obtained. Aridanin reversed the central excitatory effect of flumazenil in the methods. These results confirm the central depressant properties of Aridanin which may be mediated through GABAA receptor. |
| Uitgever: |
Asian Network for Scientific Information (provided by DOAJ) |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 25 van 28 gevonden artikelen
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