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| Titel: |
Anti-Nociceptive Effects and the Mechanism of Palisota hirsuta K. Schum. Leaf Extract in Murine Models |
| Auteur: |
E. Woode E. Boakye-Gyasi G.K. Ainooson C. Ansah M. Duwiejua |
| Verschenen in: |
International journal of pharmacology |
| Paginering: | Jaargang 5 (2009) nr. 2 pagina's 101-113 |
| Jaar: |
2009 |
| Inhoud: |
The anti-nociceptive effect of an ethanolic leaf extract of Palisota hirsuta, a plant used locally in Ghana for various painful conditions was assessed, using various pain models. Palisota hirsuta extract (PHE) together with morphine and diclofenac (positive controls), all showed significant dose-dependent anti-nociceptive activity in all the models used, that is the tail withdrawal test, the inflammatory-induced mechanical hyperalgesia test, the acetic acid induced writhing test and the formalin test. The anti-nociceptive effect exhibited by PHE in the formalin test was reversed by the systemic administration of the non-selective opioid antagonist, naloxone, the NO synthase inhibitor, Nω-nitro-arginine methyl ester (L-NAME) and the ATP-sensitive K+ channel inhibitor, glibenclamide. However, theophyline, a non-selective adenosine receptor antagonist did not reverse this effect. PHE, unlike morphine, did not induce tolerance to its anti-nociceptive effect in the formalin test after chronic administration and also morphine tolerance did not cross-generalize to PHE. Overall, the present results demonstrate that the anti-nociceptive effects of PHE might partially or wholly be due to the stimulation of peripheral opioid receptors through the activation of the nitric oxide-cyclic GMP-ATP-sensitive K+ (NO/cGMP/K+ATP)-channel pathway without tolerance induction after chronic administration. |
| Uitgever: |
Asian Network for Scientific Information (provided by DOAJ) |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 3 van 15 gevonden artikelen
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