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| Titel: |
Hepatoprotective Activity of Livobond A Polyherbal Formulation Against CCl4 Induced Hepatotoxicity in Rats |
| Auteur: |
Usha S. Satyapal Vilasrao J. Kadam Rumi Ghosh |
| Verschenen in: |
International journal of pharmacology |
| Paginering: | Jaargang 4 (2008) nr. 6 pagina's 472-476 |
| Jaar: |
2008 |
| Inhoud: |
In the present study, Livobond was evaluated for its hepatoprotective effects against carbon tetrachloride-induced hepatocellular injury in rats. Hepatotoxicity was induced in male Sprague-Dawley rats by intraperitoneal injection of CCl4 (1.5 mL kg-1) in olive oil (1:1). Livobond at a dose of 500 and 750 mg/kg/day and silymarin standard 50 mg/kg/day was administered orally for 7 days. The hepatoprotective effect of Livobond and standard was evaluated by the assay of biochemical parameters viz., alanine aminotransaminase (ALT), aspartate aminotransaminase (AST), alkaline phosphatase (ALP), total and direct bilirubin, liver lipid peroxidation, total proteins, catalase and by histopathological studies of the liver. The toxic effects of CCl4 in Livobond treated group was controlled significantly by restoration of the levels of serum bilirubin, proteins and enzymes as compared to the CCl4 treated and silymarin treated groups. Histopathological studies further confirmed the hepatoprotective activity of Livobond. The results suggest that Livobond is able to significantly alleviate the hepatotoxicity induced by CCL4 and may be attributed to the antioxidant property of the formulation. |
| Uitgever: |
Asian Network for Scientific Information (provided by DOAJ) |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 13 van 28 gevonden artikelen
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