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                                       Details for article 12 of 24 found articles
 
 
  Evaluation of the Chemoprotective Role of N-Acetylcysteine on Cisplatin-Induced Nephrotoxicity: New Aspect of an Old Drug
 
 
Title: Evaluation of the Chemoprotective Role of N-Acetylcysteine on Cisplatin-Induced Nephrotoxicity: New Aspect of an Old Drug
Author: Amany A. Abdin
Eman I. Draz
Naglaa I. Sarhan
Appeared in: International journal of pharmacology
Paging: Volume 4 (2008) nr. 5 pages 339-351
Year: 2008
Contents: This study aimed to evaluate the chemoprotective role of N-acetylcysteine on experimental cisplatin-induced nephrotoxicity. Forty albino rats were divided into 4 groups (10 rats each); Group 1: normal control. Group 2: induced nephrotoxicity (cisplatin 1 mg/kg/day i.p, 7 days). Group 3: treated 1 h before cisplatin with N-acetylcystiene orally 400 mg/kg/day, 7 days. Group 4: treated 1 h after cisplatin with N-acetylcystiene in the same dose and duration. Cisplatin-induced nephrotoxicity (group 2) caused higher levels of serum creatinine and urea with marked DNA fragmentation, significant increase in caspase-3 reaction and significant increase in proximal convoluted tubules vacuolations when compared to the control group. N-acetylcysteine 1 h after cisplatin offered marked protection in comparison to its administration 1 h before cisplatin, manifested as significant amelioration of all studied parameters. In conclusion, N-acetylcysteine 1 h after cisplatin could be recommended as a well-tolerated effective chemoprotective therapy against the potential cisplatin nephrotoxicity. For the future, further researches are needed to judge the confliction about the effects of timing and different dosage regimen of N-acetylcysteine on the antitumor efficacy of cisplatin in various types of tumors.
Publisher: Asian Network for Scientific Information, Pakistan (provided by DOAJ)
Source file: Elektronische Wetenschappelijke Tijdschriften
 
 

                             Details for article 12 of 24 found articles
 
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