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| Titel: |
Evaluation of the Chemoprotective Role of N-Acetylcysteine on Cisplatin-Induced Nephrotoxicity: New Aspect of an Old Drug |
| Auteur: |
Amany A. Abdin Eman I. Draz Naglaa I. Sarhan |
| Verschenen in: |
International journal of pharmacology |
| Paginering: | Jaargang 4 (2008) nr. 5 pagina's 339-351 |
| Jaar: |
2008 |
| Inhoud: |
This study aimed to evaluate the chemoprotective role of N-acetylcysteine on experimental cisplatin-induced nephrotoxicity. Forty albino rats were divided into 4 groups (10 rats each); Group 1: normal control. Group 2: induced nephrotoxicity (cisplatin 1 mg/kg/day i.p, 7 days). Group 3: treated 1 h before cisplatin with N-acetylcystiene orally 400 mg/kg/day, 7 days. Group 4: treated 1 h after cisplatin with N-acetylcystiene in the same dose and duration. Cisplatin-induced nephrotoxicity (group 2) caused higher levels of serum creatinine and urea with marked DNA fragmentation, significant increase in caspase-3 reaction and significant increase in proximal convoluted tubules vacuolations when compared to the control group. N-acetylcysteine 1 h after cisplatin offered marked protection in comparison to its administration 1 h before cisplatin, manifested as significant amelioration of all studied parameters. In conclusion, N-acetylcysteine 1 h after cisplatin could be recommended as a well-tolerated effective chemoprotective therapy against the potential cisplatin nephrotoxicity. For the future, further researches are needed to judge the confliction about the effects of timing and different dosage regimen of N-acetylcysteine on the antitumor efficacy of cisplatin in various types of tumors. |
| Uitgever: |
Asian Network for Scientific Information (provided by DOAJ) |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 11 van 24 gevonden artikelen
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