|
| << vorige | volgende >> |
Tijdschrift beschrijving
Alle jaargangen van het bijbehorende tijdschrift
Alle afleveringen van het bijbehorende jaargang
Alle artikelen van de bijbehorende aflevering
Details van artikel 24 van 28 gevonden artikelen
| Titel: |
MMP-13 Inhibitory Activity of Thirteen Selected Plant Species from Okinawa |
| Auteur: |
Changwei Ao Anping Li Abdelnaser A. Elzaawely Shinkichi Tawata |
| Verschenen in: |
International journal of pharmacology |
| Paginering: | Jaargang 4 (2008) nr. 3 pagina's 202-207 |
| Jaar: |
2008 |
| Inhoud: |
The methanol extracts of thirteen medicinal plants from Okinawa, Japan were examined for Matrix Metalloproteinase-13 (MMP-13) inhibitory activity. Among the thirteen selected species, Curcuma longa, Ocimum basilicum and Curcuma aromatica showed high inhibitory effect with IC50 values of 27.8, 81.7 and 85.8 μg mL-1, respectively. The chemical compositions of these three plant extracts were determined by LC-MS. Curcumin was the predominant constituent of C. longa and C. aromatica (58.6 and 28.7 mg g-1 extract, respectively), whilst O. basilicum mainly contained rosmarinic acid with amount of 47.3 mg g-1 extract. Both of curcumin and rosmarinic acid exhibited excellent MMP-13 inhibitory activity (IC50: 3.6 and 2.9 μM, respectively). The results indicate that curcumin and rosmarinic acid might be potent MMP-13 natural inhibitors. |
| Uitgever: |
Asian Network for Scientific Information, Pakistan (provided by DOAJ) |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 24 van 28 gevonden artikelen
| << vorige | volgende >> |