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Details for article 23 of 28 found articles
| Title: |
MMP-13 Inhibitory Activity of Thirteen Selected Plant Species from Okinawa |
| Author: |
Changwei Ao Anping Li Abdelnaser A. Elzaawely Shinkichi Tawata |
| Appeared in: |
International journal of pharmacology |
| Paging: | Volume 4 (2008) nr. 3 pages 202-207 |
| Year: |
2008 |
| Contents: |
The methanol extracts of thirteen medicinal plants from Okinawa, Japan were examined for Matrix Metalloproteinase-13 (MMP-13) inhibitory activity. Among the thirteen selected species, Curcuma longa, Ocimum basilicum and Curcuma aromatica showed high inhibitory effect with IC50 values of 27.8, 81.7 and 85.8 μg mL-1, respectively. The chemical compositions of these three plant extracts were determined by LC-MS. Curcumin was the predominant constituent of C. longa and C. aromatica (58.6 and 28.7 mg g-1 extract, respectively), whilst O. basilicum mainly contained rosmarinic acid with amount of 47.3 mg g-1 extract. Both of curcumin and rosmarinic acid exhibited excellent MMP-13 inhibitory activity (IC50: 3.6 and 2.9 μM, respectively). The results indicate that curcumin and rosmarinic acid might be potent MMP-13 natural inhibitors. |
| Publisher: |
Asian Network for Scientific Information (provided by DOAJ) |
| Source file: |
Elektronische Wetenschappelijke Tijdschriften |
Details for article 23 of 28 found articles
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