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| Titel: |
The Butanol Extract of Mitragyna ciliata Root: Potential as a Trypanocide |
| Auteur: |
H.A. Ogbunugafor V.I. Okochi J. Okpuzor O.S. Odesanmi F.J. Ebigwe |
| Verschenen in: |
International journal of pharmacology |
| Paginering: | Jaargang 4 (2008) nr. 2 pagina's 102-107 |
| Jaar: |
2008 |
| Inhoud: |
Bioassay guided-fractionation of Mitragyna ciliata Aubrev and Pellegr (Rubiaceae) ethanolic root extract at 100 mg kg-1 in T. brucei infected rats indicated that the bioactive constituent reside is present in the butanol fraction (inhibition = 66.61%). In vitro investigation of the extract revealed that it had low (25.55%) antioxidative property. Chemical analysis of the active fraction showed that it consists of alkaloids. The extract`s fraction had no effect on the heamatological profile of treated rats which remained consistent with the major characteristics of trypanosomiasis-anaemia, leucocytopaenia and thrombocytopaenia. Results of the in vivo evaluation of calcium concentration showed a significant difference (p<0.05), between the active butanol fraction (2.53 ± 0.036 mmol L-1) and the untreated/infected (17.79 ± 0.034 mmol L-1). A correlation existed between calcium concentration and parasiteamia in the active fraction (r = 0.40, p = 0.488) and the infected/untreated (r = -0.60, p = 0.29). These observations suggest that the active agent had an effect on the calcium metabolism in the animals which was deleterious to the parasites. |
| Uitgever: |
Asian Network for Scientific Information (provided by DOAJ) |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 31 van 32 gevonden artikelen
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