Digitale Bibliotheek
Sluiten Bladeren door artikelen uit een tijdschrift
 
<< vorige    volgende >>
     Tijdschrift beschrijving
       Alle jaargangen van het bijbehorende tijdschrift
         Alle afleveringen van het bijbehorende jaargang
           Alle artikelen van de bijbehorende aflevering
                                       Details van artikel 16 van 32 gevonden artikelen
 
 
  Comparing Oral Gabapentin Versus Clonidine as Premedication on Early Postoperative Pain, Nausea and Vomiting after General Anesthesia
 
 
Titel: Comparing Oral Gabapentin Versus Clonidine as Premedication on Early Postoperative Pain, Nausea and Vomiting after General Anesthesia
Auteur: Sussan Soltani Mohammadi
Mirsadegh Seyedi
Verschenen in: International journal of pharmacology
Paginering: Jaargang 4 (2008) nr. 2 pagina's 153-156
Jaar: 2008
Inhoud: This study was designed to compare the effects of small dose of oral gabapentin with clonidine as premedication; on early postoperative pain, nausea and vomiting (PONV) in patients undergoing elective abdominal surgeries under general anesthesia. In a randomized placebo controlled study, 120 ASA I and II patients scheduled for elective abdominal surgeries were randomly assigned to receive either 0.2 mg oral clonidine (n = 40), 300 mg gabapentin (n = 40) or placebo (n = 40) 1 h before surgery. They anesthetized with the same technique. Demographic data, post operative pain scores, nausea and vomiting and total morphine consumption by PCA pump after the operation were recorded in the recovery room and during first 6 h after the operation. VAS score more than 3 points assumed clinically important for postoperative pain management. Demographic data was not statistically different between the study groups. Two patients in gabapentin compared with 13 patients in Clonidine group (p = 0.01) and 29 patients in placebo group (p = 0.014) had VAS >3 in recovery room. The mean morphine consumption were 4.75 ± 7.5 mg in placebo, 1.95 ± 5.51 mg in Clonidine and 1.56 ± 1.5 mg in gabapentin group in recovery (Clonidine vs placebo, p = 0.032; gabapentin vs placebo, p = 0.024; gabapentin vs Clonidine, p = 0.045). These measurements were 18 ± 15.8, 13.1 ± 12.6, 12.1 ± 12.9 mg during first 6 h after operation; in placebo, Clonidine and gabapentin groups, respectively (Clonidine vs placebo, p = 0.017; gabapentin vs placebo, p = 0.023; gabapentin vs Clonidine, p = 0.067). PONV was not statistically different between the study groups in the recovery room and during first 6 h after the operation. This study showed that oral premedication with 300 mg gabapentin reduce postoperative pain and total morphine consumption but not PONV during recovery and first 6 h after abdominal surgeries.
Uitgever: Asian Network for Scientific Information (provided by DOAJ)
Bronbestand: Elektronische Wetenschappelijke Tijdschriften
 
 

                             Details van artikel 16 van 32 gevonden artikelen
 
<< vorige    volgende >>
 
 Koninklijke Bibliotheek - Nationale Bibliotheek van Nederland