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| Titel: |
A Simplistic Individualization Method for 6-Mercaptopurine in Acute Lymphoblastic Leukemia Children |
| Auteur: |
Ganping Zhou Zuofu Cai Shedian Zhou Zhichun Feng Feng Xu |
| Verschenen in: |
International journal of pharmacology |
| Paginering: | Jaargang 4 (2008) nr. 1 pagina's 64-66 |
| Jaar: |
2008 |
| Inhoud: |
The aim of this study was set up a simplistic but low-cost method for 6-mercaptopurine (6-MP) individualization chemotherapy for Acute Lymphoblastic Leukemia (ALL) children in developing China. The blood samples of ten ALL children with 6-MP chemotherapy were collected in the morning on 7th day and 14th day of the onset of therapy respectively and 6-thioguanine nucleotides (6-TGN) levels in Red Blood Cell (RBC) were measured by RP-HPLC (reverse phase-high performance liquid chromatography). Meanwhile on 14th day and 21st day the blood samples of ten ALL children were collected in the morning respectively and determined White Blood Cell (WBC) counts to monitor myelotoxicity. The ideal target level range of 6-TGN was set up between 275~750 pmol/8x108 RBC. If the level of 6-TGN in the sample of 7th day was more than 1000 pmol/8x108 RBC, the 6-MP dose starting since 8th day was adjusted to 50% of the original dose. If the level of 6-TGN in the sample of 7th day was more than 750 pmol/8x108 RBC, the 6-MP dose starting since 8th day was adjusted to 60% of the original dose. The results showed that the 6-TGN levels in ten ALL children ranged from 264~866 pmol/8x108 RBC in the samples of 7th day. Among them only two children had high levels of 6-TGN more than 750 pmol/8x108 RBC who showed after-effect myelotoxicity with low WBC on 14th day. After the adjustment of 6-MP dose since 8th day, ten ALL children had 6-TGN levels ranging from 270~450 pmol/8x108 RBC and no one had a high level of 6-TGN on 14th day. On 21st day ten ALL children had normal WBC counts and showed no myelotoxicity. We concluded that the 6-MP dose adjustment by 6-TGN levels is a simplistic but low-cost individualized method for 6-MP chemotherapy in ALL children in developing China. |
| Uitgever: |
Asian Network for Scientific Information, Pakistan (provided by DOAJ) |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 8 van 22 gevonden artikelen
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