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| Titel: |
Impact of Sildenafil Citrate (Viagra) and Ethanol Interaction on Antioxidant Defense System in the Adult Male Albino Rats |
| Auteur: |
T.G. Sivasankaran R. Udayakumar K. Panjamurthy V. Albert Singh |
| Verschenen in: |
International journal of pharmacology |
| Paginering: | Jaargang 3 (2007) nr. 1 pagina's 55-60 |
| Jaar: |
2007 |
| Inhoud: |
The interactive effects of Sildenafil citrate (VIAGRA) and Ethanol Consumption on the antioxidant defense system in testis tissue of rats were studied in the present research work. Male Albino rats were divided into eight groups of six animals each. Control rats were administered normal saline orally. While experimental animals were fed Sildenafil citrate (VIAGRA) (1 μg gm-1) and 18% ethanol (5 g kg-1 Body weight) and sacrificed. A significant depletion of GSH content in testis was observed. This combination was found to be decreased Super Oxide Dismutase (SOD) activity in testis. Thio Barbituric Acid Reactive Substrate (TBARS) and Catalase (CAT) Activity were observed to be increased in testis. In contrast, Glutathione Peroxidase (GPx) activity was decreased in testis. The results are discussed in detail. |
| Uitgever: |
Asian Network for Scientific Information (provided by DOAJ) |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 11 van 20 gevonden artikelen
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