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| Titel: |
Antihyperglycemic, Antihyperlipidemic and Antioxidant Effects of Zizyphus spina christi and Zizyphus jujuba in Alloxan Diabetic Rats |
| Auteur: |
Hala M. Hussein Eman M. El-Sayed Aataa A. Said |
| Verschenen in: |
International journal of pharmacology |
| Paginering: | Jaargang 2 (2006) nr. 5 pagina's 563-570 |
| Jaar: |
2006 |
| Inhoud: |
The present research aims to investigate the effects of methanol extracts of Zizyphus spina christi (ZSC) and Zizyphus jujuba (ZJ) roots for the treatment of alloxan diabetic rats. Sixty rats were included in the study; they were divided into six groups. The first group, non-diabetic control rats received distilled water. The 2nd and the third groups, non-diabetic control rats were given oral dose of ZSC and ZJ extracts (100 mg kg-1 body weight). The fourth group, diabetic control rats received distilled water. The fifth and sixth groups, diabetic rats were given an oral dose of ZSC and ZJ extracts (100 mg kg-1 body weight). Fasting serum glucose was measured every week and the period of the treatment continued for 2 weeks. Serum insulin, lipid profiles, liver and kidney functions were measured at the end of the experiment. In diabetic rats both extracts significantly reduced fasting serum glucose level (p<0.001) and markedly increased serum insulin level (p<0.001). ZJ significantly reduced serum total lipids (TL), triglycerides (TG), total cholesterol (TC) and lipid peroxides (LP) (p<0.001), low density lipoprotein cholesterol (LDL-C) (p<0.05), but no significant difference on high density lipoprotein cholesterol (HDL-C). Meanwhile, ZSC caused a noticeable decrease in TC, TG (p<0.05) and LP (p<0.001) compared with the untreated diabetic rats. ZJ significantly decreased alanine transaminase (ALT), aspartate transaminase (AST) and total bilirubin (TB) (p<0.001) in diabetic rats. Serum creatinine and urea showed significant reduction in diabetic rats treated with ZSC extract. Both extracts produced no significant changes in all studied parameters except for a significant reduction of serum lipid peroxides and urea by ZJ extract as compared to untreated diabetic control. Present data revealed that both extracts of ZSC and ZJ have beneficial effects on diabetic rats. They reduce hyperglycemia, hyperlipidemia and lipid peroxides that associate diabetes. Besides, they were safe towards liver and kidney functions. The effect of ZJ is more pronounced than that of ZSC. |
| Uitgever: |
Asian Network for Scientific Information (provided by DOAJ) |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
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