|
| << vorige | volgende >> |
Tijdschrift beschrijving
Alle jaargangen van het bijbehorende tijdschrift
Alle afleveringen van het bijbehorende jaargang
Alle artikelen van de bijbehorende aflevering
Details van artikel 12 van 30 gevonden artikelen
| Titel: |
Effect of Bio-adhesive Polymers like HPMC, Gelatin, Na-CMC and Xanthan Gum on Theophylline Release from Respective Tablets |
| Auteur: |
Sharif Mohammad Shaheen Md. Nazir Hossen Kazi Mehedul Islam Maruf Ahmed Md. Shah Amran Mamunur Rashid |
| Verschenen in: |
International journal of pharmacology |
| Paginering: | Jaargang 2 (2006) nr. 5 pagina's 504-508 |
| Jaar: |
2006 |
| Inhoud: |
In order to evaluate the feasible application of bio-adhesive polymers like HPMC-15 cps and 50 cps; gelatin; Na-CMC and xantham gum in sustained release dosage form (SRDF), tablets containing various amount of bio-adhesive polymers with a model drug like anhydrous Theophylline sodium glycinate were prepared by compression in a hydraulic press (Perkin Elmer) compression machine using 5 ton pressure. The release characteristics of Theophylline (TH) from sustained release tablets were analyzed in triplicate using a thermal shaker (Memmert) with a shaking speed of 50 rpm at 37±0.5°C in 250 mL of simulated gastric fluid without enzyme for 8 h. At the end of 8 h of dissolution it was found that 61.60% (for 300 mg HPMC-15 cps) and 42.92% (for 500 mg HPMC-15 cps) of TH was released from HPMC-15 cps based tablets, respectively. When HPMC-15cps was increased to 50 cps, 52.12 and 59.66% of TH was released, respectively. Both concentration and viscosity depended sustained release of TH was found. 74.13 and 94.15% of TH was released from Gelatin based SR tablets of the same concentrations, respectively. Gelatin also showed the same concentration effects i.e. release was reduced with an increase in concentration of polymer. 52.40 and 50.95% of TH was released from Na-CMC based SR tablets of the same concentrations, respectively and that of 76.96 and 78.26% of TH from xanthan gum based tablets. It means that there was no remarkable concentration effect of these two polymers on the TH release. In all cases there was almost zero order release fashion. Bio-adhesive polymers like HPMC and gelatin might be successfully applicable in SRDF rather than Na-CMC and xanthan gum studied here. |
| Uitgever: |
Asian Network for Scientific Information (provided by DOAJ) |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 12 van 30 gevonden artikelen
| << vorige | volgende >> |