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| Titel: |
Vasorelaxant Effect of Sildenafil on Aorta and Pulmonary Artery in Rabbits |
| Auteur: |
Niyazi Gler Hanefi Ozbek Beyhan Eryonucu |
| Verschenen in: |
International journal of pharmacology |
| Paginering: | Jaargang 2 (2006) nr. 1 pagina's 55-59 |
| Jaar: |
2006 |
| Inhoud: |
This <i>in vitro </i>study was designed to determine the direct vasorelaxant effect of the sildenafil on isolated rabbit pulmonary artery and compare it with the response of isolated rabbit aorta. Endothelium intact aortic and pulmonary artery rings from seven domestic rabbits were suspended in organ chambers containing 15 mL Krebs solution aerated with 95% O<sub>2</sub>, 5% CO<sub>2</sub>. In both phenylephrine and potassium chloride (KCl) precontracted vessels, relaxant responses of sildenafil were recorded by strain gauge transducers connected to a polygraph. Sildenafil (10 <sup>9</sup> to 310 <sup>5</sup> M) induced a dosedependent vasodilation of phenylephrine precontracted aorta and pulmonary artery; 55 and 95% relaxations were obtained, respectively, at a concentration of 310 <sup>5</sup> M. Sildenafil also caused a dose-dependent vasodilation of KCl-precontracted aorta and pulmonary artery, but this vasodilation was significantly lesser. Sildenafil-induced relaxations were higher in pulmonary arteries when compared to aortic rings precontracted with either phenylephrine or KCl. We concluded that sildenafil induces a dose-dependent vasodilation on phenylephrine and KCl-precontracted rabbit aorta and pulmonary artery. This vasodilatory effect is more potent in pulmonary arteries than in aortic rings. |
| Uitgever: |
Asian Network for Scientific Information (provided by DOAJ) |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
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