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Details for article 3 of 20 found articles
| Title: |
Determination of Rofecoxib in Serum with Pre-column Derivatization and Fluorescence Detection |
| Author: |
Mohsen Amini Morteza Pirali-Hamedani Hossein Ali Ebrahimi Majid Darabi Abbas Shafiee |
| Appeared in: |
International journal of pharmacology |
| Paging: | Volume 1 (2005) nr. 4 pages 332-335 |
| Year: |
2005 |
| Contents: |
A HPLC method for determination of rofecoxib in human serum was presented. The method is based on pre-column derivatization of analyte to a phenanthrene derivative of drug. Rofecoxib and internal standard were extracted from serum using liquid-liquid extraction. Upon exposure to UV light, drug was found to undergo a phtocyclization reaction giving a species with high absorbance. Validation of the method has been studied in the concentration range of 2-100 ng mL-1. |
| Publisher: |
Asian Network for Scientific Information (provided by DOAJ) |
| Source file: |
Elektronische Wetenschappelijke Tijdschriften |
Details for article 3 of 20 found articles
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