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| Titel: |
What is the Opposite of a Receptor Reserve? |
| Auteur: |
T.J. Feuerstein W. Sauermann |
| Verschenen in: |
International journal of pharmacology |
| Paginering: | Jaargang 1 (2005) nr. 2 pagina's 195-202 |
| Jaar: |
2005 |
| Inhoud: |
There are semilogarithmic (lg-) concentration-response sigmoids with slopes exactly representing the opposite asymmetry of that encountered in the case of a receptor reserve (reserve: large curvature in the left part of the curve and narrow curvature in the right part; opposite: narrow curvature in the left part of the curve and large curvature in the right part). In addition, the binding K < SUB>d < /SUB>s of agonists are smaller than their EC < SUB>50 < /SUB> in such curves. Using experimental concentration-response data a non-linear fitting model of a receptor "antireserve" was developed which is the topic of the present paper. This model reflects the possibility of a subthreshold preactivation of a signaling system. Hypothetically, only after exceeding this threshold a receptor-mediated response takes place. |
| Uitgever: |
Asian Network for Scientific Information (provided by DOAJ) |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 19 van 19 gevonden artikelen
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