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| Titel: |
Implementation of the technique in isolated organ vascular as tool for the validation of medicinal plants: Study of the vasodilator effect of the S. scutellarioides |
| Auteur: |
Jorge Hernán Ramírez Mauricio Palacios Oscar Gutiérrez |
| Verschenen in: |
Colombia médica |
| Paginering: | Jaargang 38 (2007) nr. 1 pagina's 34-39 |
| Jaar: |
2007 |
| Inhoud: |
Introduction: Salvia scutellarioides is a plant with antihypertensive and diuretic properties. In this study, its vasodilator effect is evaluated using the isolated organ technique.Objectives: To standardize the isolated vascular organ, and to study the effect of S. scutellarioides in vasoconstriction by a1 receptors stimulation.Methodology: Rat aortic rings were placed in an organ bath equipment (BIOPAC®), at 37o C temperature and constant carbogen gas bubbling. Tension changes were registered with an isometric tension transducer and data acquisition equipment. During the standardization, six curves of concentration-tension with phenylephrine at 1, 3 and 5 hours were registered, in order to determine maximum tension (TM), and the effective concentration 50 (EC50). Finally, three concentration-tension curves were obtained for phenylephrine with S. scutellarioides at a concentration of 10 mg/dl and 20 mg/dl. Results: During the technique standardization, no statistically significant differences were found in TM for phenylephrine at 1, 3 and 5 hours. The administration of S. scutellarioides produced a TM dose dependent reduction with no EC50 changes.Discussion: The implemented isolated organ technique is viable up to 5 hours, and does not produce a1 receptors desensibilization. The TM diminution by S. scutellarioides is explained by a non competitive a1 antagonism effect. Studies to isolate active principles for allowing the initiation of phase I human clinical trials are required. |
| Uitgever: |
Corporación Editora Médica del Valle (provided by DOAJ) |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 55 van 105 gevonden artikelen
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