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| Titel: |
Antitumour and anti-inflammatory activities in a hydroethanolic extract of Lindackeria paludosa, a South American shrub |
| Auteur: |
Ana Laura FAZIO Diana BALLÉN Italo M. CESARI María Jesús ABAD Miriam ARSENAK Omar ESTRADA Peter TAYLOR |
| Verschenen in: |
Boletín latinoamericano y del Caribe de plantas medicinales y aromáticas |
| Paginering: | Jaargang 9 (2010) nr. 2 pagina's 143-150 |
| Jaar: |
2010 |
| Inhoud: |
Lindackeria paludosa (Benth.) Gilg is a shrub found mainly in the north of South America and is known as Sarakura in Venezuela. In the light of local reports on the traditional use this member of the Flacourtiaceae family, we investigated the effect of a hydroethanolic extract of the bark (LP) on parameters of the inflammatory response (tumour necrosis factor alpha [TNF-], interleukin-6 [IL-6] and nitric oxide [NO]) and its potential antitumour activity both in vitro and in vivo. LP was notably cytotoxic for only one tumour cell line (A549, IC50 = 64 ¿g/ml), but not for the other cell types. However, LP did inhibit production of the inflammatory mediators, as well as the growth of primary tumours and metastases in C57BL/6 mice, but did not inhibit nuclear factor B (NF-B) activity. Thus, LP appears to inhibit tumour growth without being directly cytotoxic to tumour cells, possibly by interfering with protumour inflammatory processes. |
| Uitgever: |
Sociedad Latinoamericana de Fitoquímica (provided by DOAJ) |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
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