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                                       Details for article 9 of 14 found articles
 
 
  Genotoxicity assessment of water extracts of Ocimum gratissimum, Morinda lucida and Citrus medica using the Allium cepa assay
 
 
Title: Genotoxicity assessment of water extracts of Ocimum gratissimum, Morinda lucida and Citrus medica using the Allium cepa assay
Author: Bernice M. OYEDARE
Adekunle A. BAKARE
Akeem AKINBORO
Appeared in: Boletín latinoamericano y del Caribe de plantas medicinales y aromáticas
Paging: Volume 8 (2009) nr. 2 pages 97-103
Year: 2009
Contents: Herbal preparations may be with a single or combination of herbs. With continuous and uncontrolled use of medicinal plants, there may be sufficient exposure to permit the expression of genotoxicity. In this study, the genotoxicity of water extract of Ocimum gratissimum (Linn.) alone, and in combination with Morinda lucida (Benth.); and combination of Morinda lucida extract and Citrus medica (Linn.) juice were investigated using the Allium cepa test. Leaves of O. gratissimum and M. lucida and juice of C. medica were used to prepare the extracts as practiced locally. Roots of Allium cepa were exposed to 1, 2.5, 5, 10 and 25 % concentrations (v/v) of each of the extracts for 24 and 48 h, respectively for cytological analysis. Tap water was utilized as the control. All the extracts caused a statistically significant (p< 0.05) concentration dependent suppression of mitotic activity in root tip cells of Allium cepa. The extract of O. gratissimum induced binucleated cells at different concentrations. The mixture of the extracts of O. gratissimum and M. lucida totally inhibited cell division at the highest tested concentration indicating blockage of the cell cycle at the interphase stage. Data on the combination of extracts indicate interaction of the herb constituents. These observations suggest cytotoxic and mitodepressive effects of the extracts on A. cepa cells.
Publisher: Sociedad Latinoamericana de Fitoquímica (provided by DOAJ)
Source file: Elektronische Wetenschappelijke Tijdschriften
 
 

                             Details for article 9 of 14 found articles
 
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